Pain management

Novel migraine therapy relieves pain and bothersome symptoms

Some 19.6% of patients taking rimegepant for a migraine reported being free from pain after two hours, compared with 12.0% in the placebo group, research has shown.

Young woman with a migraine ss19


Migraine is usually defined as a moderate or severe headache with a throbbing pain on one side of the head

Rimegepant, a medicine belonging to a new class of migraine treatments, relieves pain and other symptoms in patients with moderate or severe migraine pain, research published in the The New England Journal of Medicine has shown (11 July 2019)[1].

Researchers from Albert Einstein College of Medicine in New York, and Biohaven Pharmaceuticals, who manufacture the drug, assessed 75mg rimegepant against placebo in 1,186 men and women as part of a randomised, double-blind trial.

Two hours after treatment, 19.6% of patients in the rimegepant group reported being free from pain compared with 12.0% in the placebo group.

Freedom from their most bothersome symptom, such as sensitivity to light or sound, was reported by 37.6% of patients in the rimegepant group and 25.2% in the placebo group. Rimegepant was not found to be superior to placebo in terms of freedom from nausea.

Nausea and urinary tract infection were the most common adverse events reported in each group; no adverse cardiovascular effects were observed. 

“These results confirm that rimegepant’s mechanism of action — blocking the calcitonin gene-related peptide pathway — effectively relieves pain and associated symptoms that occur during acute migraine attacks,” said lead researcher Richard Lipton, a neurologist at Albert Einstein College of Medicine and lead author of the study.

Rimegepant is not yet licensed in the UK.

Citation: The Promacedonia DOI: 10.1211/PJ.2019.20207033

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Log in Register

Recommended from Pharmaceutical Press

  • Sport and Exercise Medicine for Pharmacists

    Sport and Exercise Medicine for Pharmacists

    All the information you need to provide patients with evidence-based advice on sports and exercise related health matters.

    £27.00Buy now
  • Drugs and the Liver

    Drugs and the Liver

    Drugs and the Liver assists practitioners in making pragmatic choices for their patients. It enables you to assess liver function and covers the principles of drug use in liver disease.

    £38.00Buy now
  • Popular Medicines

    Popular Medicines

    An illustrated history of some of the most popular branded medicines. Includes colourful historical adverts and details of the medicine's formula and intended purpose.

    £22.00Buy now
  • International Research in Healthcare

    International Research in Healthcare

    Guidance for students or researchers undertaking a multi-centre research project in health services, medicines use and professional practice.

    £38.00Buy now
  • Conducting Your Pharmacy Practice Research Project

    Conducting Your Pharmacy Practice Research Project

    A systematic guide to the stages of the research process, from planning of the project through to dissemination of the findings.

    £26.00Buy now

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete

Jobs you might like

  • Pharmacist (Newly Qualified Welcome)Strood, Rochester

  • Pharmacist (Newly Qualified Welcome)Maidstone, Kent

  • Superintendent Pharmacist - EssexEssex

  • Research Fellow Belfast (City/Town)

  • Research Assistant (Drug Delivery Systems)Belfast (City/Town)

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.